1.5 mg PO qDay initially; may increase to 3 mg/day on Day 2. Depending upon clinical response and tolerability, further dose adjustments can be made in 1.5 to 3-mg increments; dosing range is 1.5-6 mg PO qDay. Dosages >6 mg/day do not confer increased effectiveness sufficient to outweigh dose-related adverse reactions.Vraylar is the best and worst drug at the same time. I was on this medicine for 3 and a half years. Yes, it did work for me as far as my bipolar and depression. I started on the 3MG and after 2 months, my toes started twitching non-stop and it hurt. We lowered it to the 1.5MG dose and the twitching went away after a few weeks.1.5 mg PO qDay initially; may increase to 3 mg/day on Day 2. Depending upon clinical response and tolerability, further dose adjustments can be made in 1.5 to 3-mg increments; dosing range is 1.5-6 mg PO qDay. Dosages >6 mg/day do not confer increased effectiveness sufficient to outweigh dose-related adverse reactions.It can also be used as an add-on medication to help with major depressive disorder (MDD). Vraylar (cariprazine) is taken by mouth once a day. Some common side effects of this medication include uncontrolled muscle movements, headache, and restlessness. Unlike some other antipsychotic medications, Vraylar (cariprazine) causes minimal weight gain.VRAYLAR and antidepressants may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.The efficacy of VRAYLAR in the treatment of depressive episodes associated with bipolar I disorder (bipolar depression) was established in one 8-week and two 6-week placebo-controlled trials in patients (mean age of 43 years, range 18 to 65 years; 61% were female; and 75% were Caucasian) who met DSM-IV-TR or DSM-5 criteria for depressive ...A place to discuss your medical experiences with Vraylar® (cariprazine). Note: This is an independently ran subreddit NOT affiliated with Vraylar® or any medical profession. ... I was on it for anxiety, depression, and mood swings. It has nearly gotten rid of my issues. I still struggle with anxiety but it’s not nearly as bad as it used to be. VRAYLAR is different from an antidepressant. It is in a different class of medicines and is taken with an antidepressant to help improve depression symptoms. However, the exact way VRAYLAR works is unknown. Ask your healthcare provider if adding VRAYLAR to your antidepressant therapy could be right for you. VRAYLAR and antidepressant medicines may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.Oct 12, 2023 · The recommended starting dose of Vraylar for bipolar depression is 1.5 mg taken once daily. On day 15 of treatment, your doctor may increase your daily dose to 3 mg. On day 15 of treatment, your ... VRAYLAR and antidepressants may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.Cariprazine ( Vraylar) is the most recently approved atypical antipsychotic with indications for the treatment of adults with acute mania/mixed mania in bipolar I disorder and schizophrenia. 1 The atypical antipsychotics are a heterogeneous group of medications that like typical antipsychotics all have antagonistic activity on the dopamine …Oct 30, 2017 · Answers. Hi! First of all, Vraylar is not an antidepressant... it's an antipsychotic that's prescribed for schizophrenia and Bipolar disorder. It's sometimes prescribed along with an antidepressant as an add-on for the treatment of Major Depressive disorder and Treat Resistant Depression. Personally, I've been taking Vraylar for about a year ... VRAYLAR® (cariprazine) for Bipolar I or Major Depressive Disorder. Explore what’s possible with VRAYLAR. Proven to help control symptoms in the following conditions: Major depressive disorder* Bipolar I disorder* * Approved to treat adults with major depressive disorder (along with an antidepressant), and the full spectrum of bipolar I episodes: Cariprazine. Cariprazine, sold under the brand names Vraylar, Reagila and Symvenu among others, is an atypical antipsychotic developed by Gedeon Richter, [8] which is used in the treatment of schizophrenia, bipolar mania, [9] bipolar depression, [10] and major depressive disorder. [6]Introduction. Mood disorders and their treatments are undergoing major paradigm shifts both in diagnostic conceptualization and nomenclature. 1 –4 Mood disorder treatments are moving away from classical notions of ‘antidepressants’ and ‘antipsychotics,’ which have become confusing terms since classical ‘antidepressants’ are not first line …Because I work in psych I was able to pull a sort of Wolf-in-sheeps-clothing maneuver and get invited to a dinner held by Vraylar with a lecture by a highly regarded Stanford psychiatrist who runs their mood disorder program. The presentation of studies and results, coupled by the anecdotal reports and studies from the presenting psych.More about Vraylar ( cariprazine ) Ratings & Reviews. Latuda has an average rating of 6.3 out of 10 from a total of 839 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect. Vraylar has an average rating of 5.8 out of 10 from a total of 472 ratings on Drugs.com. 46% of reviewers reported a ...Jan 5, 2023 · Bottom Line. Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to cause elevations in blood sugar or total cholesterol levels, sedation, or weight gain. 5. 7%. EPS ‡. 2%. 4%. 6%. Rates of somnolence and sedation in VRAYLAR 1.5 mg/day (7%) and 3 mg/day (6%) groups were similar to placebo (4%)1. >99% of EPS and akathisia events in bipolar I depression studies were mild or moderate 17. ‡ EPS included akinesia, drooling, dyskinesia, dystonia, extrapyramidal disorder, hypokinesia, muscle tightness ...Schizophrenia is characterized by positive, negative, cognitive, and affective symptoms. Antipsychotic medications, which work by blocking the dopamine D 2 receptor, are the foundation of pharmacotherapy for schizophrenia to control positive symptoms. Cariprazine is a dopamine D 3 receptor-preferring D 3 /D 2 partial agonist antipsychotic … VRAYLAR is used for bipolar disorder, also known as manic-depressive illness. It is a brain disorder that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to ... VRAYLAR is used for bipolar disorder, also known as manic-depressive illness. It is a brain disorder that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to ... VRAYLAR (cariprazine) is indicated in adults as adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD), for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression), for the acute treatment of manic or mixed episodes associated with bipolar I disorder, and for the treatment ... VRAYLAR is a prescription medicine used in adults: along with antidepressant medicines to treat major depressive disorder (MDD) for short-term (acute) treatment of manic or mixed episodes that happen with bipolar I disorder. to treat depressive episodes that happen with bipolar I (bipolar depression)The bipolar depression studies also assessed changes in severity of symptoms of depression using the HAMD-17 and QIDS-SR16, and symptoms of anxiety using the HAM-A. A clinically significant difference of 2 or 3 points in the HAMD-17 has been suggested in the literature, although justification for this threshold was unclear and likely opinion-based.Paxil (paroxetine) Prozac (fluoxetine) Zoloft (sertraline) If you do not respond to SSRIs, your doctor may prescribe Anafranil (clomipramine). Anafranil is a tricyclic antidepressant that is FDA-approved to treat OCD. Anafranil may cause side effects such as dry mouth, blurred vision, sedation, and rapid heartbeat. It can also lead to weight gain.5 days ago ... Vraylar is an antipsychotic medication used to treat major depressive disorder (along with an antidepressant), schizophrenia, and bipolar ...The treatment of bipolar disorder changed in ways big and small in 2019. At the regulatory level, cariprazine (Vraylar) joined a select group of atypical antipsychotics with FDA-approval in bipolar depression, and lithium’s FDA-approval was broadened from age 12 and older to age 7 and older. Besides the official decrees, over a dozen ...INTRODUCTION. Depression is a common disorder, which often leads to poor quality of life and impaired role functioning. It is known to be a major contributor to the global burden of diseases and according to World Health Organization (WHO), depression is the fourth leading cause of disability worldwide and it is projected that by 2020, it will be the …VRAYLAR may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries. Seizures (convulsions) may occur with VRAYLAR and other antipsychotic drugs.Anxiety is real. Depression is real. And they both very much feed and live off of each other. Sometimes it's as if one cannot survive without the other. They ping... Edit Your...I asked to switch because I was making noticeable mistakes at work since I was so out of it I was switched to Vraylar and it has been a miracle drug for me. I take the lowest dose and it has helped with my depression, anxiety, energy, motivation, and it was starting to help with my anhedonia. It also has helped improved my stomach issues that I ...Vraylar works to improve depression symptoms in bipolar depression and major depressive disorder and to improve psychiatric signs and symptoms in schizophrenia. Vraylar capsules are taken once a day. Vraylar is thought to work by managing serotonin and dopamine levels, which are chemical messengers in the brain.VRAYLAR and antidepressant medicines may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.NEW ORLEANS -- Low-dose cariprazine (Vraylar) was associated with reductions in anxiety for patients with major depressive disorder (MDD), and the …5 days ago ... Vraylar is an antipsychotic medication used to treat major depressive disorder (along with an antidepressant), schizophrenia, and bipolar ...topiramate cariprazine. Applies to: Topamax (topiramate) and Vraylar (cariprazine) Topiramate can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like cariprazine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during …Anxiety is real. Depression is real. And they both very much feed and live off of each other. Sometimes it's as if one cannot survive without the other. They ping... Edit Your...Although the results for the 1.5 mg dose of Vraylar suggested an improvement in depressive symptoms, the results for the 3 mg dose of Vraylar were ...Vraylar for Bipolar Disorder User Reviews. Vraylar has an average rating of 5.8 out of 10 from a total of 333 reviews for the treatment of Bipolar Disorder. 46% of reviewers reported a positive experience, while 37% reported a negative experience. Filter by condition.Sep 4, 2023 · Official answer. by Drugs.com. Vraylar (cariprazine) may be taken either in the morning or at night, depending on your preference. Cariprazine, the active ingredient of Vraylar, and its metabolites have a long half-life: 2 to 4 days for cariprazine, 1 to 2 days for one active metabolite called DCAR, and approximately 1 to 3 weeks for another ... Dec 21, 2021 ... Vraylar is an atypical antipsychotic indicated for the treatment of adult patients with schizophrenia and for manic, mixed, or depressive ...INDICATIONS AND USAGE. VRAYLAR (cariprazine) is indicated in adults as adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD), for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression), for the acute treatment of manic or mixed episodes associated with bipolar I disorder, and …Proven to help control symptoms in the following conditions: Major depressive disorder*. Bipolar I disorder*. * Approved to treat adults with major depressive disorder (along with …VRAYLAR and antidepressant medicines may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.Vraylar gave me extreme restlessness and made me super jittery. Had to come off it. yes it made me anxious and gave me akathisia, i quit it. When I went on Vraylar soon after I started getting panic attacks which I haven't had in over ten years. Might be a coincidence but they got better when I stopped taking Vraylar.May 24, 2019 · To be honest, I am Bipolar and Vraylar helped me with mania but not very much for depression. As for anxiety, I take buspirone very successfully. Only about 8% of users gain weight but those who do seem to gain excessively. I gained 20 lbs on Vraylar. Best regards and good luck with your decision. Best of luck to you! Sometimes antipsychotics are prescribed off-label for depression. I take Vraylar for major depression. It’s now common for novel antipsychotics to be prescribed for depression. They are a life saver in my experience when AD …Studies have shown that some antipsychotic drugs can also treat bipolar depression. Lumateperone ( Caplyta ) and Quetiapine ( Seroquel, Seroquel XR) is used for the short-term treatment of bipolar ...The approval of Caplyta may help to raise awareness about bipolar II, which is still frequently misdiagnosed as either bipolar I disorder or unipolar depression, Aiken said. The FDA approval of Caplyta was based on positive findings from two six-week, phase 3 trials. The first trial evaluated the effects of 42 mg/day lumateperone monotherapy ...Vraylar is the best and worst drug at the same time. I was on this medicine for 3 and a half years. Yes, it did work for me as far as my bipolar and depression. I started on the 3MG and after 2 months, my toes started twitching non-stop and it hurt. We lowered it to the 1.5MG dose and the twitching went away after a few weeks.VRAYLAR® (cariprazine) Add-on Treatment for Major Depressive Disorder. Struggling with unresolved symptoms of major depressive disorder? Ask about adding VRAYLAR to …Cariprazine is marketed as VRAYLAR ® in the U.S., and in addition to being approved as an adjunctive therapy to antidepressants for the treatment of MDD in … Upon discontinuation of Vraylar, the plasma concentrations of Vraylar and its active metabolites decline in a multi-exponential manner. 1. Dosage and Administration. For the treatment of schizophrenia, the recommended dose range is 1.5 to 6 mg/day. Vraylar should be initiated at 1.5 mg/day, and the dose may be increased to 3 mg/day on day 2. Apr 10, 2023 ... Adjunctive Treatment with Cariprazine ... Compared to other antipsychotics, the atypical antipsychotic cariprazine (marketed as Vraylar) exhibits ...I take vraylar. I haven't gained weight, I don't know if it helped my anxiety because we had it pretty well controlled when I started it, and it definitely doesn't help my depression so i just started wellbutrin. I take lamictal, vraylar, gabapentin, buspar, wellbutrin, and prazosin. 1.5 mg PO qDay initially; may increase to 3 mg/day on Day 2. Depending upon clinical response and tolerability, further dose adjustments can be made in 1.5 to 3-mg increments; dosing range is 1.5-6 mg PO qDay. Dosages >6 mg/day do not confer increased effectiveness sufficient to outweigh dose-related adverse reactions. VRAYLAR® (cariprazine) for Bipolar I or Major Depressive Disorder. Explore what’s possible with VRAYLAR. Proven to help control symptoms in the following conditions: Major depressive disorder* Bipolar I disorder* * Approved to treat adults with major depressive disorder (along with an antidepressant), and the full spectrum of bipolar I episodes: INTRODUCTION. Depression is a common disorder, which often leads to poor quality of life and impaired role functioning. It is known to be a major contributor to the global burden of diseases and according to World Health Organization (WHO), depression is the fourth leading cause of disability worldwide and it is projected that by 2020, it will be the …Schizophrenia is characterized by positive, negative, cognitive, and affective symptoms. Antipsychotic medications, which work by blocking the dopamine D 2 receptor, are the foundation of pharmacotherapy for schizophrenia to control positive symptoms. Cariprazine is a dopamine D 3 receptor-preferring D 3 /D 2 partial agonist antipsychotic …If you’ve ever thought about receiving counseling or participating in therapy, you may wonder what options are available to you. Many different therapy styles can help you with anx...Aug 12, 2019 ... Vraylar (cariprazine) and Zyprexa ... Vraylar vs. Zyprexa. Medical and ... depression, seizure, anxiety), and heart or blood pressure medications.Hamilton Rating Scale for Anxiety: -1.3; -0.8; Clinical Global Impressions-Improvement: -0.3; -0.3; Vraylar belongs to the class of atypical antipsychotics, and was first FDA approved in 2015. The ...Are you drowning in student loans? Is your mental health suffering because of it? Learn how to deal with student loan debt and depression. Eric Strausman Eric Strausman I graduated...Vraylar and anxiety Depression is something I’ve dealt with for most of my life, and about 2 months ago it got bad enough to the point where I attempted suicide. One of the paths forward has been trying different meds and Vraylar is the antidepressant that I’m currently on.Vraylar for Bipolar Disorder User Reviews. Vraylar has an average rating of 5.8 out of 10 from a total of 333 reviews for the treatment of Bipolar Disorder. 46% of reviewers reported a positive experience, while 37% reported a negative experience. Filter by condition.There are 561 drugs known to interact with Vraylar (cariprazine), along with 13 disease interactions, and 5 alcohol/food interactions. Of the total drug interactions, 92 are major, 468 are moderate, and 1 is minor. Does Vraylar interact with my other drugs? Enter other medications to view a detailed report. ...Anyone taking this with lexapro or alone for major depressive disorder and anxiety? Abilify gave me a serious reaction but i dont know what—suicidal thoughts that felt like a compulsion, severe limb jerks, or darting eyes. Im on wellbutrin and lexapro. And wellbutrin gave me severe constipation and i need surgery.The starting dosage of VRAYLAR is 1.5 mg once daily and should be increased to 3 mg once daily on Day 2. The recommended dosage range is 3 mg to 6 mg once daily. Depending upon clinical response and tolerability, further dose adjustments can be made in 1.5 mg or 3 mg increments. The maximum recommended dosage is 6 mg daily.That’s akathisia I had to switch to abilfy because vraylar stopped working and the reality is I do better on no antipsychotics thank God. ... I’m not an expert in anxiety or depression …Brand name: Vraylar®. Oral capsule: 1.5mg, 3mg, 4.5mg, 6mg. All FDA warnings are at the end of this fact sheet. Please consult them before taking this medication. What Is …Bipolar disorder is a type of mood disorder that typically involves depressive episodes and manic episodes. Mixed episodes happen when symptoms of both depression and mania occur at the same time. Doctors can prescribe Vraylar for use during mixed, manic, or depressive episodes. Major depressive disorder.By affecting dopamine and serotonin, Vraylar may help ease the symptoms of schizophrenia, major depressive disorder (depression), or bipolar I disorder. As for how long Vraylar stays in your...Apr 10, 2023 ... Adjunctive Treatment with Cariprazine ... Compared to other antipsychotics, the atypical antipsychotic cariprazine (marketed as Vraylar) exhibits ...VRAYLAR is a prescription medicine approved as an add-on therapy for adults with depression who are currently taking an antidepressant but still have unresolved depression symptoms. How could VRAYLAR help me? You’ve made progress with your antidepressant, but unresolved symptoms may leave you feeling stuck.Vraylar; Descriptions. Cariprazine is used to treat schizophrenia or mania and depression related with bipolar disorder. It is also used to treat major depressive disorder (MDD). Cariprazine changes some of the chemicals in the brain that cause psychotic disorders. This medicine should not be used to treat behavioral problems in older adults ...Privacy is a basic human need, and invasion of privacy can have serious psychological and emotional consequences, including paranoia, anxiety, depression and broken trust. Invasion...It is ineffective against depression because it will not generally have an effect on specific neurotransmitters that are involved in the development of ...NEW ORLEANS -- Low-dose cariprazine (Vraylar) was associated with reductions in anxiety for patients with major depressive disorder (MDD), and the potential adjunctive therapy for this population ...venlafaxine cariprazine. Applies to: venlafaxine and Vraylar (cariprazine) Using venlafaxine together with cariprazine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.May 22, 2017 · A dopamine D 3 receptor strategy for treatment of depression or schizophrenia is based on the brain distribution and the putative role of D 3 receptors (Gross and Drescher, 2012); these receptors have the highest density in rat and human ventral striatum (Sokoloff et al., 1990; Gurevich and Joyce, 1999), one of the core areas implicated in the ... VRAYLAR is a prescription medicine used in adults: along with antidepressant medicines to treat major depressive disorder (MDD) for short-term (acute) treatment of manic or mixed episodes that happen with bipolar I disorder. to treat depressive episodes that happen with bipolar I (bipolar depression)
2.4 Recommended Dosage in Depressive Episodes Associated with Bipolar I Disorder (Bipolar Depression) The starting dosage of VRAYLAR is 1.5 mg once daily. Depending upon clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. Maximum recommended dosage is 3 mg once daily.. Project zomboid cities
The recommended starting dose of Vraylar for bipolar depression is 1.5 mg taken once daily. On day 15 of treatment, your doctor may increase your daily dose to 3 mg. On day 15 of treatment, your ...And thanks to COVID, your insurance may cover it now One of the most wide-reaching side effects of COVID-19 has been its impact on mental health. Understandably, a global pandemic ...Medications used to treat depression can increase the risk of suicidal thoughts and behaviors in younger people. This risk applies to children and adults ages 24 years and younger.Depending on your insurance coverage, eligible patients may pay as little as $5 per 30-day supply for each of up to twelve (12) prescription fills or as little as $5 for each of up to four (4) 90-day prescriptions if VRAYLAR ® (cariprazine) is covered without coverage restrictions (eg, prior authorization, step therapy, or otherwise), and for ...Patients and their families should watch out for new or worsening depression or thoughts of suicide. Also watch out for sudden changes in feelings such as ...She is also diagnosed with a comorbid condition, posttraumatic stress disorder (PTSD). The patient has been prescribed Vraylar (cariprazine) 1.5 milligrams (mg) ...Bipolar disorder is a chronic mood disorder characterized by episodes of mania (or hypomania), depression, and periods with normal mood (euthymia) [].Two forms of bipolar disorder are bipolar I disorder, which requires a history of at least one manic episode, and bipolar II disorder, which requires a history of at least 1 hypomanic episode …VRAYLAR and antidepressant medicines may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions.NEW ORLEANS -- Low-dose cariprazine (Vraylar) was associated with reductions in anxiety for patients with major depressive disorder (MDD), and the … Cariprazine. Cariprazine, sold under the brand names Vraylar, Reagila and Symvenu among others, is an atypical antipsychotic developed by Gedeon Richter, [8] which is used in the treatment of schizophrenia, bipolar mania, [9] bipolar depression, [10] and major depressive disorder. [6] 2.4 Recommended Dosage in Depressive Episodes Associated with Bipolar I Disorder (Bipolar Depression) The starting dosage of VRAYLAR is 1.5 mg once daily. Depending upon clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. Maximum recommended dosage is 3 mg once daily.Eligible patients whose insurer does not cover VRAYLAR (cariprazine) or where coverage restrictions have not been satisfied may pay as little as $75 per 30-day supply for each of up to twelve (12) prescription fills. When insurance covers VRAYLAR (cariprazine), eligible patients may pay as little as $15 for each of up to four (4) 90-day ...Jun 16, 2022 ... There is even evidence for increased mortality risk in otherwise-healthy adult patients with depression receiving antipsychotic augmentation of ...Cariprazine Capsules. Cariprazine is a medication that treats mental health conditions like schizophrenia and bipolar disorder. It balances the levels of dopamine and serotonin in your brain. These substances help regulate your mood, behaviors and thoughts. You can take these capsules by mouth with a glass of water as directed.Only four are FDA-approved in bipolar depression: cariprazine (Vraylar ... Schiöler H, et al. Quetiapine monotherapy as treatment for anxiety symptoms in patients with bipolar depression: a pooled analysis of results from 2 double-blind, randomized, placebo-controlled studies. Prim Care Comp J Clin Psychiatry. 2009;11:215-225.Abstract. Cariprazine is an atypical antipsychotic currently under investigation as an adjunctive to antidepressant treatment (ADT) for patients with major depressive …Aug 23, 2023 · Depressive episodes associated with bipolar I disorder (bipolar depression) Adjunctive treatment with an antidepressant therapy (ADT) for major depressive disorder (MDD). Cariprazine, under the brand name Vraylar, became an FDA-approved medicine on September 17, 2015. Cariprazine side effects Common cariprazine side effects may include: VRAYLAR effectively treats bipolar I depression and acute manic or mixed episodes of bipolar I in adults, providing full-spectrum relief for all bipolar I symptoms. But controlling the mood swings of bipolar I disorder is about …VRAYLAR is a prescription medicine used in adults: along with antidepressant medicines to treat major depressive disorder (MDD) for short-term (acute) treatment of manic or mixed episodes that happen with bipolar I disorder. to treat depressive episodes that happen with bipolar I (bipolar depression).